There are reports that IS has taken control of the Kurdish headquarters in the town, but this has been denied by a Syrian Kurdish official there.
Kobane has been a major battleground for IS and the Kurds for three weeks.
The fighting has forced hundreds of thousands of Syrians, mainly Kurds, to flee into neighbouring Turkey, which has so far ruled out any ground operation on its own against IS.
Kurdish forces, who are being helped by US-led coalition strikes against IS, say they urgently need more weapons and ammunition to push back the militants' advance in the town.
The US Central Command (Centcom) said that US fighter jets alongside UAE and Saudi Arabian military aircraft carried out airstrikes on Thursday and Friday around the southeast of Kobane and in Deir al-Zour, in eastern Syria, destroying several IS vehicles and training facilities.
'No Srebrenica'
Except for one narrow entry and exit point, Mr de Mistura said Kobane was "literally surrounded" by IS, with hundreds of mainly elderly civilians still inside the city centre and another 10-13,000 gathered nearby, AFP reports.
He said the civilians would "most likely massacred'' if the town fell to IS, warning that the UN did not want to see another Srebrenica - where thousands of Muslim men and boys were killed by Bosnian Serb forces in 1995 during the Bosnian conflict.
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